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Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
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Related Experiment Video

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Primary Central Nervous System Lymphomas: A Single-Center Experience.

Sidika Gulkan Ozkan1, Seyedehtina Safaei2, Ali Kimiaei2

  • 1Division of Hematology, Department of Internal Medicine, Bahcesehir University Faculty of Medicine, Istanbul, Türkiye; Adult Hematology and Bone Marrow Transplantation Unit, Medical Park Göztepe Hospital, Istanbul, Türkiye.

Sisli Etfal Hastanesi Tip Bulteni
|April 14, 2025
PubMed
Summary

Methotrexate-based regimens and autologous stem cell transplantation (ASCT) show efficacy in treating primary central nervous system lymphoma (PCNSL), achieving high response rates. However, significant toxicities and mortality highlight ongoing challenges in managing this aggressive lymphoma.

Keywords:
Non-Hodgkin lymphomaPCNSLprimary central nervous system lymphoma

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Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
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Area of Science:

  • Oncology
  • Hematology
  • Neurology

Background:

  • Primary central nervous system lymphoma (PCNSL) is a rare, aggressive non-Hodgkin lymphoma (NHL) confined to the brain and spinal cord.
  • Effective treatment strategies for PCNSL remain a critical area of research due to its challenging nature and potential for poor outcomes.

Purpose of the Study:

  • To investigate the clinical characteristics, treatment approaches, and patient outcomes for primary central nervous system lymphoma (PCNSL).
  • To evaluate the efficacy and safety of current treatment modalities, including methotrexate-based chemotherapy and autologous stem cell transplantation (ASCT), in PCNSL patients.

Main Methods:

  • Retrospective analysis of 11 immunocompetent patients with PCNSL treated between October 2022 and July 2024.
  • Evaluation of patient demographics, clinical presentation, treatment regimens (including HDMTX and R-MPV), ASCT details, toxicities, and survival outcomes.

Main Results:

  • The majority of patients (90.91%) had diffuse large B-cell lymphoma; 81% were fit for HDMTX treatment.
  • High complete response rates (80%) were observed with initial treatment, with R-MPV being the most common first-line regimen.
  • Autologous stem cell transplantation (ASCT) was performed in 72.73% of patients, but associated with significant toxicities (50%) and transplant-related mortality (25%). Cerebellar involvement correlated with higher mortality (p=0.045).

Conclusions:

  • Methotrexate-based regimens and ASCT demonstrate effectiveness in achieving high response rates for PCNSL.
  • Significant treatment-related toxicities and mortality persist, underscoring the challenges in managing PCNSL.
  • Further research, including larger prospective studies, is necessary to optimize PCNSL treatment and address associated complications.