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Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

19
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
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Dissociative Identity Disorder01:30

Dissociative Identity Disorder

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Dissociative Identity Disorder (DID), previously termed multiple personality disorder, is a complex psychological condition characterized by the presence of two or more distinct identities or personality states. Each identity exhibits unique patterns of behavior, voice, and mannerisms and may possess separate memories and emotional responses. The alternating control between identities can result in memory gaps and challenges in recalling daily activities, often exacerbating the individual's...
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Related Experiment Video

Updated: May 13, 2025

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

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Resolving Heterogeneity in Posttraumatic Stress Disorder Using Individualized Structural Covariance Network Analysis.

Xueling Suo1,2,3, Nanfang Pan1,2,3, Li Chen1,2,3

  • 1Department of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China.

Depression and Anxiety
|April 14, 2025
PubMed
Summary

Posttraumatic stress disorder (PTSD) shows significant brain structural diversity, falling into two distinct neuroanatomical subtypes. These subtypes, identified using individual differential structural covariance networks (IDSCN), may help personalize PTSD diagnosis and treatment.

Keywords:
PTSDheterogeneityindividual differential structural covariance networkpsychoradiologysubtypes

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Posttraumatic stress disorder (PTSD) is clinically heterogeneous, complicating understanding and treatment.
  • Identifying neurobiological subgroups within PTSD is crucial for targeted interventions.

Purpose of the Study:

  • To investigate neuroradiological subgroups within PTSD using structural covariance networks.
  • To explore the relationship between structural brain variations and PTSD symptom severity.

Main Methods:

  • Constructed individual differential structural covariance networks (IDSCN) based on cortical thickness from T1-weighted MRI scans.
  • Analyzed data from 89 individuals with PTSD and 89 matched trauma-exposed non-PTSD controls.
  • Utilized hierarchical clustering to identify structural subtypes within the PTSD group.

Main Results:

  • PTSD patients displayed significant diversity in structural covariance edges, primarily in default mode, ventral attention, and sensorimotor networks.
  • These structural variations correlated with individual PTSD symptom severity.
  • Two distinct neuroanatomical subtypes of PTSD were identified, differing in frontal cortex structural covariance.

Conclusions:

  • Structural covariance deviations are common in PTSD and manifest in at least two subtypes.
  • These findings illuminate the neurobiological underpinnings of PTSD heterogeneity.
  • This research may facilitate personalized diagnostic and therapeutic approaches for PTSD.