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Neutrophils and Neutrophil-Based Drug Delivery Systems in Anti-Cancer Therapy
Hicham Wahnou1, Riad El Kebbaj2, Soufyane Hba1,3
1Laboratory of Immunology and Biodiversity, Faculty of Sciences Ain Chock, Hassan II University, B.P 2693, Maarif, Casablanca 20100, Morocco.
Cancers
|April 14, 2025
Summary
Neutrophils have a dual role in cancer, promoting or fighting tumors. Understanding their plasticity and targeting them offers new cancer immunotherapy strategies.
Area of Science:
- Oncology
- Immunology
- Cell Biology
Background:
- Neutrophils are key white blood cells with a complex role in cancer.
- They can either promote tumor growth and immune suppression or exhibit anti-tumorigenic properties.
Purpose of the Study:
- To review the dual role of neutrophils in the tumor microenvironment (TME).
- To explore mechanisms of neutrophil plasticity and their therapeutic potential in cancer.
Main Methods:
- Literature review of neutrophil functions in cancer progression.
- Analysis of neutrophil interactions within the TME.
- Examination of neutrophil-based drug delivery and immunotherapy strategies.
Main Results:
- Neutrophils can adopt pro-tumorigenic phenotypes (e.g., via NETs, cytokines, VEGF, MMPs) or anti-tumorigenic phenotypes (e.g., via ROS, ADCC, CTL/NK cell activation).
- Neutrophil-mimicking nanoparticles and modulated neutrophil activity show promise for targeted cancer therapy and immunotherapy.
Conclusions:
- Neutrophil plasticity in the TME presents significant therapeutic opportunities.
- Targeting neutrophil functions can enhance existing treatments and develop novel immunotherapies for improved patient outcomes.
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