Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

27
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
27
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

45
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
45
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

77
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
77
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

38
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
38
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

20
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
20
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

27
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
27

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activation of the endocytosis pathway stratifies subtypes and therapeutic sensitivity in colorectal cancer.

Research square·2026
Same author

Molecular Diagnosis, Clinical Trial Representation, and Precision Medicine in Minority Patients with Oncogene-Driven Lung Cancer.

Cancers·2025
Same author

Modulating autophagy in KRAS mutant colorectal cancer using combination of oncolytic reovirus and carbamazepine.

PloS one·2025
Same author

Molecular Characterization and Clinical Outcomes of Pancreatic Neuroendocrine Neoplasms Harboring PAK4-NAMPT Alterations.

JCO oncology advances·2025
Same author

The Role of WDR77 in Cancer: More than a PRMT5 Interactor.

Molecular cancer research : MCR·2025
Same author

Distinct Molecular and Clinical Features of Specific Variants of KRAS Codon 12 in Pancreatic Adenocarcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research·2025

Related Experiment Video

Updated: May 5, 2026

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
10:42

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

Published on: July 6, 2022

3.4K

Infectious Agents and Esophageal Cancer: A Comprehensive Review.

Ahan Bhatt1,2, Hasan Musanna Zaidi3,4, Radhashree Maitra5,6

  • 1Jacobi Medical Center, Bronx, NY 10461, USA.

Cancers
|April 14, 2025
PubMed
Summary

Infectious agents like human papillomavirus (HPV) show a strong link to esophageal squamous cell carcinoma (ESCC). However, evidence for other pathogens in esophageal cancer remains weak, necessitating further research.

Keywords:
Epstein–Barr virusGERDHelicobacter pyloricytomegalovirusesophageal adenocarcinomaesophageal cancerherpes simplex virushuman papillomavirusoncogenesissquamous cell carcinoma

More Related Videos

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

3.8K
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

979

Related Experiment Videos

Last Updated: May 5, 2026

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
10:42

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

Published on: July 6, 2022

3.4K
Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

3.8K
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

979

Area of Science:

  • Oncology
  • Infectious Diseases
  • Gastroenterology

Background:

  • Esophageal cancer, including squamous cell carcinoma (ESCC) and adenocarcinoma (EAC), is a major global cause of cancer mortality.
  • While established risk factors are known, the role of infectious agents in esophageal cancer etiology is under investigation.
  • Understanding these associations is crucial for developing effective prevention and treatment strategies.

Purpose of the Study:

  • To review the existing literature on the association between infectious agents and esophageal cancer.
  • To evaluate the strength of evidence for various pathogens implicated in ESCC and EAC development.

Main Methods:

  • Comprehensive literature review of studies investigating infectious agents and esophageal cancer.
  • Analysis of the strength and consistency of evidence for each identified agent.

Main Results:

  • Human papillomavirus (HPV), particularly HPV 16 and 18, demonstrates the strongest association with ESCC.
  • The link between high-risk HPV (hr-HPV) and EAC is less conclusive.
  • Helicobacter pylori (H. pylori) has a complex, debated role in EAC, with some evidence suggesting a protective effect.
  • Epstein-Barr virus (EBV) is rarely associated with esophageal lymphoepithelial carcinoma; other agents like HSV, polyomaviruses, and Candida show varying degrees of association.

Conclusions:

  • Current evidence implicating infectious agents in esophageal cancer is largely weak and sometimes conflicting.
  • HPV is the most strongly associated pathogen, particularly with ESCC.
  • Further research is essential to confirm etiologic roles and guide clinical interventions for esophageal cancer prevention and treatment.