Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

5.0K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
5.0K
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

2.4K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Topology-Preserving Elastic Deformation Augmentation Enables Robust Defect Detection in Data-Scarce Industrial Imagery.

ACS macro letters·2026
Same author

Phase-transition-like behaviors of sequence-selective dynamic bonds.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Fully Automated Inverse Co-Optimization of Templates and Block Copolymer Blending Recipes for Directed Self-Assembly Lithography.

ACS applied materials & interfaces·2026
Same author

Ginsenoside-based nanoliposomes co-delivering ergothioneine and coenzyme Q10 to combat skin aging via mitochondrial modulation.

Colloids and surfaces. B, Biointerfaces·2025
Same author

IgG-Bridging-Seeded Synergistic Aggregation of SARS-CoV-2 Spikes Underlies Potent Neutralization by a Low-Affinity Antibody.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Madecassoside-functionalized platinum-based liposomes for sensitive skin: Enhancing rapid soothing and barrier homeostasis.

Colloids and surfaces. B, Biointerfaces·2025

Related Experiment Video

Updated: May 13, 2025

Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics
09:10

Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics

Published on: August 25, 2022

3.0K

Dynamic Interplay between Deformability and Activity in Cell Entry of Soft Active Nanoparticles.

Haixiao Wan1, Zheng Jiao1, Jiaqi Li1

  • 1State Key Laboratory of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, P. R. China.

Nano Letters
|April 14, 2025
PubMed
Summary

Cellular uptake is influenced by nanoparticle deformability. Soft elastic active nanoparticles show nonmonotonic uptake efficiency dependent on rigidity, unlike passive nanoparticles, offering insights for biomedical applications.

Keywords:
BiophysicsCellular uptakeDeformabilityNanomedicineSoft active nanoparticle

More Related Videos

Forming, Confining, and Observing Microtubule-Based Active Nematics
08:37

Forming, Confining, and Observing Microtubule-Based Active Nematics

Published on: January 13, 2023

2.5K
Quantifying Cytoskeleton Dynamics Using Differential Dynamic Microscopy
06:37

Quantifying Cytoskeleton Dynamics Using Differential Dynamic Microscopy

Published on: June 15, 2022

3.4K

Related Experiment Videos

Last Updated: May 13, 2025

Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics
09:10

Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics

Published on: August 25, 2022

3.0K
Forming, Confining, and Observing Microtubule-Based Active Nematics
08:37

Forming, Confining, and Observing Microtubule-Based Active Nematics

Published on: January 13, 2023

2.5K
Quantifying Cytoskeleton Dynamics Using Differential Dynamic Microscopy
06:37

Quantifying Cytoskeleton Dynamics Using Differential Dynamic Microscopy

Published on: June 15, 2022

3.4K

Area of Science:

  • Biophysics
  • Cellular Biology
  • Nanotechnology

Background:

  • Cellular uptake is crucial for biological processes and drug delivery.
  • Nanoparticle deformability is a known factor in cellular uptake.
  • Nonequilibrium interactions at cell-nanoparticle interfaces are not well understood.

Purpose of the Study:

  • To investigate the role of nanoparticle rigidity in nonequilibrium cellular uptake.
  • To explore the dynamics of soft elastic active nanoparticles during endocytosis.
  • To understand the interplay between nanoparticle deformability, activity, and cellular interactions.

Main Methods:

  • Computational simulations of soft elastic active nanoparticles.
  • Analysis of endocytosis processes.
  • Development of analytical theories for nonequilibrium physics.

Main Results:

  • Uptake efficiency exhibits a nonmonotonic dependence on nanoparticle rigidity.
  • Active nanoparticles show different behavior compared to passive ones.
  • A minimum activity threshold is identified for cellular uptake.
  • Rigidity influences nanoparticle orientation during uptake.

Conclusions:

  • Nanoparticle deformability significantly regulates nonequilibrium interactions during cellular uptake.
  • The findings provide a deeper understanding of the physics governing cell-nanoparticle interfaces.
  • This research offers potential for designing soft active systems for biomedical applications.