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Update on hepatitis C virus management.

Austin D Peer1, Jennifer C Price

  • 1Department of Medicine, University of California, San Francisco, San Francisco, California, USA.

Current Opinion in Gastroenterology
|April 14, 2025
PubMed
Summary
This summary is machine-generated.

Hepatitis C virus (HCV) can be cured in most patients with direct-acting antiviral (DAA) therapy. Achieving HCV elimination requires increased screening, simplified treatment access, and addressing barriers for at-risk populations.

Keywords:
direct-acting antiviralshepatitis C virushepatitis C virus eliminationsimplified hepatitis C virus treatment algorithm

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Area of Science:

  • Hepatology
  • Infectious Diseases
  • Public Health

Background:

  • Hepatitis C virus (HCV) significantly contributes to liver disease and mortality despite effective treatments.
  • Direct-acting antiviral (DAA) therapy offers high cure rates for HCV infections.

Purpose of the Study:

  • To review current HCV treatment approaches, including simplified algorithms.
  • To discuss management strategies for special patient populations.
  • To explore future directions for HCV interventions and elimination.

Main Methods:

  • Review of current literature on HCV treatment and management.
  • Analysis of simplified treatment algorithms for non-specialist providers.
  • Examination of advancements in diagnostics and their impact on care access.

Main Results:

  • Pan-genotypic DAA regimens demonstrate high efficacy and are manageable by non-specialists.
  • Simplified treatment algorithms aid decision-making for treatment-naive patients.
  • Point-of-care diagnostics can improve screening and linkage to care, but barriers and stigma persist.

Conclusions:

  • HCV elimination is achievable with a comprehensive strategy.
  • Increased screening, simplified treatment access, and reduced stigmatization are crucial.
  • Addressing healthcare disparities and treatment barriers are vital for meeting elimination targets.