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Related Experiment Video

Updated: Jun 14, 2026

Liquid-cell Transmission Electron Microscopy for Tracking Self-assembly of Nanoparticles

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Published on: October 16, 2017

Tracking Spatially Heterogeneous Dynamics of Single Nanoparticles Near Liquid-Solid Interfaces.

Tian Zhao¹, Chia-Ying Wang¹, Jhih-Wei Chu²

¹Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.

The Journal of Physical Chemistry. B

|April 14, 2025

Summary

Researchers experimentally validated the Faxén-Brenner theory for nanoscale particles near a fluid-wall interface. This confirms fluid dynamics predictions for particle diffusion at the nanoscale.

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Area of Science:

Colloidal physics
Nanoscale fluid dynamics
Statistical mechanics

Background:

The behavior of particles near interfaces is crucial in colloidal physics.
Faxén and Brenner's continuum mechanics solutions predict distance- and direction-dependent particle diffusivity.
Experimental validation for micron-sized particles exists, but nanoscale applicability is unclear.

Purpose of the Study:

To experimentally test the complete Faxén-Brenner solutions on the nanoscale.
To investigate nanoparticle diffusivity near a fluid-wall interface.
To bridge the gap between theoretical predictions and experimental evidence at the nanoscale.

Main Methods:

Developed a novel multiresolution instrument for simultaneous nanoscale tracking and interface localization.
Utilized high-resolution lifetime-gated 3D tracking of single nanoparticles.
Employed two-photon laser-scanning microscopy for precise nanoparticle-wall proximity measurements.

Main Results:

Successfully reproduced the predicted directional diffusivity divarication at the single-nanoparticle level.
Achieved experimental validation of the Faxén-Brenner theory down to approximately 65 nm.
Demonstrated agreement with theoretical predictions without adjustable parameters.

Conclusions:

The study provides the first direct experimental support for Faxén-Brenner solutions on the nanoscale.
Fluid dynamics principles governing particle diffusion are validated for nanoparticles near interfaces.
Future research should focus on the sub-100 nm regime, considering finite-temperature fluctuations and fluid molecularity.