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18F-AV45 PET-CT screening for systemic amyloidosis: A case report
1Zhuji People's Hospital of Zhejiang Province, Shaoxing, China.
Rationale:
Systemic AL amyloidosis is a complex, multi-system disease with diverse clinical manifestations. Early and definite diagnosis helps to improve the prognosis.
Patient Concerns:
At the beginning stage of the disease, the patient only presented with liver enlargement and abnormal liver function.
Diagnoses:
Conventional echocardiography "ECG" amyloidosis screening spot tracking imaging, etc. Pathology is the gold standard for diagnosis.
Interventions:
Elimination of clonal plasma cells or B cells that produce abnormal light chains. For eligible patients, autologous stem cell transplantation is the first choice.
Outcomes:
Systemic AL amyloidosis is often misdiagnosed due to a lack of typical symptoms and imaging signs.
Lessons:
This case highlights the patients with atypical clinical manifestations of AL amyloidosis, and the diagnosis should be made early to improve the prognosis. If there are risks and difficulties in pathological diagnosis, the cumulative organs can be indirectly evaluated with 18F-florbetapir positron emission tomography-computed tomography. Subsequent indirect diagnosis through less invasive, more accessible abdominal or rectal tissue.
