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Related Experiment Video

Updated: May 13, 2025

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

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Herpetic keratitis after corneal crosslinking.

N Laaribi1, R Mendes1, K Reda1

  • 1Department of Ophthalmology, Mohammed V Military Teaching Hospital, Medical School, University of Mohammed V, Rabat, Morocco.

Archivos De La Sociedad Espanola De Oftalmologia
|April 14, 2025
PubMed
Summary

Corneal crosslinking for keratoconus can rarely lead to herpetic keratitis (HK). Early diagnosis and treatment with antivirals are crucial for healing and preventing vision loss.

Keywords:
CrosslinkigCrosslinkingHerpeticHerpéticoKeratitisKeratoconusQueratitisQueratocono

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Corneal Surgery

Background:

  • Corneal crosslinking (CXL) is a standard treatment for progressive keratoconus.
  • While generally safe, rare sight-threatening complications can occur post-CXL.

Observation:

  • A 40-year-old woman developed severe pain and photophobia after CXL for keratoconus.
  • Clinical examination revealed corneal stromal infiltrates and epithelial defects.
  • Polymerase chain reaction confirmed Herpes Simplex Virus type 1 (HSV-1) as the cause.

Findings:

  • The patient was diagnosed with new-onset herpetic keratitis (HK) post-corneal crosslinking.
  • Treatment with oral valacyclovir, topical corticosteroids, and lubricants led to healing of the epithelial defect and reduced stromal infiltrate.

Implications:

  • This case highlights the potential risk of developing herpetic keratitis following corneal crosslinking.
  • Ophthalmologists must consider HK in the differential diagnosis of post-CXL complications, even without a prior history of HSV infection.
  • Prompt diagnosis and management are essential for favorable outcomes in post-CXL herpetic keratitis.