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Prognostic role of transcription factor ARID1A in patients with endometrial cancer of no specific molecular profile (NSMP) subtype

  • 0Department of Obstetrics and Gynecology, Division of General Gynecology and Gynecologic Oncology, Medical University of Vienna, Vienna, Austria.
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society +

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April 14, 2025

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April 14, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

ARID1A mutations in no specific molecular subtype (NSMP) endometrial cancer indicate a higher risk of recurrence. This finding suggests ARID1A can serve as a prognostic biomarker for personalized treatment strategies.

Area Of Science

  • Gynecologic Oncology
  • Molecular Pathology
  • Cancer Biomarkers

Background

  • Over 50% of newly diagnosed endometrial cancers lack specific molecular subtypes (NSMP).
  • Improved molecular subtyping is needed for better prognostic accuracy.
  • Established biomarkers for NSMP endometrial cancer are limited.

Purpose Of The Study

  • To evaluate the prognostic value of ARID1A mutations in endometrial cancers classified as NSMP.
  • To determine if ARID1A status can predict recurrence risk in NSMP endometrial cancer.
  • To explore ARID1A as a potential biomarker for personalized treatment.

Main Methods

  • Retrospective analysis of prospectively collected molecular profiling and clinical data (August 2017 - June 2022).
  • Tumor specimens assessed via mismatch repair protein IHC and next-generation sequencing.
  • ARID1A mutational status correlated with recurrence risk, progression-free survival (PFS), and disease-specific survival (DSS) in the NSMP cohort.

Main Results

  • Of 127 endometrial cancer patients, 72 had NSMP tumors (56.7%).
  • ARID1A mutations were found in 33.3% (24/72) of NSMP cases.
  • ARID1A mutations significantly increased recurrence risk (OR 4.20, p=0.018) and impaired PFS (HR 3.96, p=0.009), confirmed in multivariable analysis.

Conclusions

  • ARID1A mutations identify NSMP endometrial cancer patients with a higher risk of recurrence.
  • ARID1A shows potential as a prognostic biomarker for NSMP endometrial cancer.
  • Clinical validation of ARID1A assessment could enhance sub-classification and personalize treatment.

Keywords:

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