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Related Experiment Video

Updated: May 16, 2025

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Shuangshi Tonglin Capsule Improves Prostate Fibrosis through Nrf2/TGF-β1 Signaling Pathways.

Zi-Qiang Wang1, Peng Mao2, Bao-An Wang2

  • 1School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi Province, 712046, China.

Chinese Journal of Integrative Medicine
|April 14, 2025
PubMed
Summary

Shuangshi Tonglin Capsules (SSTL) effectively treat prostate fibrosis (PF) by reducing cell proliferation and collagen deposition. The treatment mechanism involves regulating the Nrf2/TGF-β1 signaling pathway and mitigating oxidative stress.

Keywords:
Chinese medicineShuangshi Tongling Capsulesnuclear factor erythroid 2-related factor 2/heme oxygenase-1pathwayprostate fibrosistransforming growth factor-β1/Smad pathway

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Area of Science:

  • Urology
  • Pharmacology
  • Cell Biology

Background:

  • Prostate fibrosis (PF) is a significant pathological change.
  • Understanding the therapeutic mechanisms of traditional Chinese medicine for PF is crucial.

Purpose of the Study:

  • To investigate the therapeutic effects and underlying mechanisms of Shuangshi Tonglin Capsules (SSTL) in treating prostate fibrosis (PF).

Main Methods:

  • Established in vitro (WPMY-1 cells) and in vivo (Sprague-Dawley rats) models of PF.
  • Assessed cell proliferation, migration, and collagen deposition.
  • Analyzed key markers including FGF-23, E2, PSA, and oxidative stress indicators.
  • Investigated the Nrf2/HO-1 and TGF-β1/Smad signaling pathways using Western blot and qRT-PCR.

Main Results:

  • SSTL significantly inhibited prostate stromal cell proliferation, migration, and collagen deposition in vitro and in vivo.
  • SSTL treatment reduced prostate index, improved glandular morphology, and decreased levels of FGF-23, E2, and PSA.
  • SSTL ameliorated oxidative stress and modulated the Nrf2/HO-1 and TGF-β1/Smad pathways, as evidenced by altered protein and mRNA expression levels.

Conclusions:

  • Shuangshi Tonglin Capsules demonstrate significant efficacy in treating prostate fibrosis.
  • The therapeutic effects are attributed to the modulation of the Nrf2/TGF-β1 signaling pathway and the reduction of oxidative stress.