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Updated: May 13, 2025

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

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Comprehensive analysis of prognosis and tumor immune microenvironment of cuproptosis-related gene CDKN2A in lung

Teng Song^1,2,3, Shuping Li^1,2,3, Ke Zhao^1,2,3

¹Department of Oncology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, 300121, China.

BMC Pulmonary Medicine

|April 14, 2025

Summary

Cuproptosis-related genes (CRGs) are implicated in lung adenocarcinoma (LUAD). CDKN2A is identified as a prognostic biomarker in LUAD, potentially guiding immunotherapy strategies.

Keywords:

CDKN2A Cuproptosis-Related genes Immunotherapy Lung adenocarcinoma Prognosis

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Area of Science:

Oncology
Molecular Biology
Cancer Research

Background:

Cell death mechanisms significantly influence tumor heterogeneity and anti-tumor immunity.
The role of cuproptosis-related genes (CRGs) in lung adenocarcinoma (LUAD) is largely unexplored.

Purpose of the Study:

To investigate the expression and prognostic value of CRGs in LUAD.
To identify potential biomarkers for LUAD prognosis and immunotherapy.

Main Methods:

Analysis of 19 CRGs expression in LUAD using TCGA data.
Consensus clustering to identify LUAD subtypes.
Validation of CDKN2A expression and prognostic significance across multiple datasets.
Gene set enrichment analysis (GSEA) and immune cell infiltration assessment.

Main Results:

Fifteen CRGs were differentially expressed in LUAD.
Two LUAD subtypes were identified, with one associated with poor prognosis.
Elevated CDKN2A expression correlated with adverse outcomes and differential immune cell infiltration.

Conclusions:

CDKN2A shows potential as a prognostic biomarker for LUAD.
Findings may inform the development of novel immunotherapeutic strategies for LUAD patients.