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Updated: May 23, 2025

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples

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A Large-Scale Retrospective Study of Serum Des-Gamma-Carboxy Prothrombin as a Diagnostic Marker of HCC: Effect of

Hongying Bu¹, Weijia Luo², Wenli Tao²

¹School of Public Health, Hengyang Medical School, University of South China, Hengyang, China.

Journal of Clinical Laboratory Analysis

|April 15, 2025

Summary

Serum des-gamma-carboxy prothrombin (DCP) shows promise as a biomarker for hepatocellular carcinoma (HCC). However, liver function can affect its diagnostic accuracy, potentially leading to false positives.

Keywords:

AFP DCP HCC retrospective study serum biomarker

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Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy

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Published on: June 18, 2020

Area of Science:

Hepatobiliary Medicine
Oncology Diagnostics
Biomarker Research

Background:

Hepatocellular carcinoma (HCC) diagnosis relies on accurate biomarkers.
Serum des-gamma-carboxy prothrombin (DCP) is a potential biomarker for HCC.

Purpose of the Study:

Evaluate the diagnostic accuracy of serum DCP for HCC.
Identify factors influencing DCP's diagnostic performance.

Main Methods:

Retrospective multicenter study of 4555 subjects.
Collected clinical data including medical history, treatments, serum tests, and imaging.
Analyzed serum DCP levels across various liver and non-liver conditions.

Main Results:

Serum DCP concentrations were significantly higher in HCC patients (9086.00 ± 366.10 mAU/mL) compared to other diseases (p < 0.05).
At a threshold of 40.00 mAU/mL, serum DCP showed positive rates of 85.11% in HCC.
Diagnostic specificity of serum DCP for HCC was influenced by liver function; AFP levels also increased in HCC.

Conclusions:

Serum DCP demonstrates potential as an optimal biomarker for HCC diagnosis.
Liver function status is a critical factor influencing DCP accuracy and requires careful consideration to avoid false positives.