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The effect of GLP-1 receptor agonists on circulating inflammatory markers in type 2 diabetes patients: A systematic

Yifan Ren1,2,3,4, Yuzhang Chen1,2,3,4, Wenbin Zheng1,2,3,4

  • 1Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Diabetes, Obesity & Metabolism
|April 15, 2025
PubMed
Abstract

Insights

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) significantly reduce inflammation markers like CRP and IL-6 in type 2 diabetes patients. This study highlights GLP-1 RAs as a potential therapeutic strategy for managing inflammation alongside blood glucose control.

Area of Science:

  • Endocrinology
  • Pharmacology
  • Immunology

Background:

  • Type 2 diabetes mellitus (T2DM) is associated with chronic inflammation.
  • Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are established antidiabetic agents.
  • The anti-inflammatory potential of GLP-1 RAs requires further investigation.

Conclusions:

  • GLP-1 RAs demonstrate significant anti-inflammatory properties in patients with T2DM.
  • These findings support the use of GLP-1 RAs for managing inflammation in T2DM.
  • The results may inform future therapeutic strategies involving GLP-1 RAs.
Keywords:
CRPGLP‐1 RAsIL‐6glucagon‐like peptide‐1 receptor agonistsinflammationmeta‐analysis

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