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Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions

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Microfluidic osmotic compression with operando meso-structure characterization using SAXS.

Dimitri Radajewski¹, Pierre Roblin¹, Patrice Bacchin¹

¹Laboratoire de Génie Chimique, Université de Toulouse, CNRS, INPT, UPS, Toulouse, France. yannick.hallez@univ-tlse3.fr.

|April 15, 2025

Summary

This summary is machine-generated.

Researchers created a microfluidic chip for nanoliter-scale osmotic compression. This allows real-time structural analysis using small-angle X-ray scattering (SAXS) on laboratory beamlines, advancing colloidal science.

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Area of Science:

Colloid and Surface Science
Materials Science
Biophysics

Background:

Microfluidic devices enable precise control over small sample volumes.
Small-angle X-ray scattering (SAXS) is a powerful technique for characterizing nanoscale structures.
Adapting synchrotron-based techniques to laboratory settings is crucial for broader accessibility.

Purpose of the Study:

To develop and validate a microfluidic chip for in situ and operando osmotic compression at the nanoliter scale.
To enable SAXS measurements compatible with laboratory X-ray sources.
To demonstrate the capability of tracking colloidal particle behavior during compression.

Main Methods:

Fabrication of a novel microfluidic chip designed for laboratory beamlines.
On-chip osmotic compression of silica colloidal particles (Ludox TM-50).
In situ and operando structural analysis using small-angle X-ray scattering (SAXS).
Monitoring X-ray absorbance and modeling scattered signals to track volume fraction.

Main Results:

Successful demonstration of osmotic compression and SAXS measurements on a microfluidic chip at a laboratory beamline.
Accurate tracking of colloidal particle volume fraction during compression.
Validation of the method for determining equations of state for colloidal suspensions.

Conclusions:

The developed microfluidic chip facilitates high-throughput, low-sample-volume structural analysis of colloidal systems.
This technology enables unambiguous determination of equations of state by precisely controlling osmotic pressure and salt chemical potential.
The chip has broad applications in understanding colloidal behavior, crystallization, nucleation, and interaction potentials.