Application of human cardiac organoids in cardiovascular disease research

Area of Science:

• Biomedical Engineering
• Cardiovascular Research
• Regenerative Medicine

Background:

• Conventional animal models for cardiovascular disease (CVD) exhibit limitations in clinical translation due to interspecies variations.
• Human cardiac organoids (hCOs) are emerging as a powerful in vitro platform for studying CVD.
• hCOs offer a more human-relevant model for investigating cardiac pathologies.

Purpose of the Study:

• To provide a comprehensive review of human cardiac organoids (hCOs) in cardiovascular disease (CVD) research.
• To explore the applications of hCOs in modeling various cardiac conditions and aiding therapeutic development.
• To discuss the future potential and challenges of hCOs in clinical translation.

Main Methods:

• Review of existing literature on human cardiac organoids (hCOs).
• Analysis of hCO applications in modeling myocardial infarction, heart failure, arrhythmias, and congenital heart diseases.
• Examination of hCOs' utility in drug screening and therapeutic strategy development.

Main Results:

• hCOs effectively replicate disease mechanisms and pathophysiological processes of various cardiovascular conditions.
• hCOs demonstrate significant potential for drug screening and the development of novel therapeutic strategies.
• The review highlights the versatility of hCOs across different CVD models.

Conclusions:

• Human cardiac organoids (hCOs) represent a significant advancement in cardiovascular disease (CVD) modeling.
• Despite challenges in technical complexity and standardization, hCOs hold great promise for clinical translation.
• Integration with multi-omics and AI technologies will further enhance the utility of hCOs in CVD research and treatment.