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Diffuse myocardial infiltration in secondary cardiac lymphoma: A case report

Dan Huang1, Chunyan Wu1, Liming Xiao1

  • 1Department of Nuclear Medicine, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology, Mianyang, Sichuan 621000, P.R. China.

Oncology Letters
|April 15, 2025
PubMed

Insights

Secondary cardiac lymphoma, often diffuse large B-cell lymphoma, presents nonspecific symptoms. This case highlights thymic lymphoma invading the heart, showing significant regression after chemotherapy but leading to myocardial changes.

Area of Science:

  • Cardiology
  • Oncology
  • Radiology

Background:

  • Secondary cardiac lymphoma is rare and challenging to diagnose due to nonspecific symptoms, often resulting in poor prognosis.
  • Diffuse large B-cell lymphoma (DLBCL) can manifest primarily in the heart, posing diagnostic and therapeutic difficulties.

Observation:

  • A 53-year-old male presented with thymic DLBCL with extensive cardiac infiltration.
  • Initial diagnosis was aided by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT), confirming diffuse myocardial invasion.

Findings:

  • Chemotherapy led to significant regression of cardiac lymphoma lesions.
  • Post-treatment imaging revealed myocardial necrosis and fibrosis, complicated by a left ventricular aneurysm.

Implications:

  • This case underscores the importance of considering cardiac lymphoma in patients with unexplained cardiac symptoms and extranodal lymphoma.
  • Multimodality imaging, including PET/CT, is crucial for diagnosis, staging, and monitoring treatment response in cardiac lymphoma.
  • Understanding post-treatment myocardial changes is vital for managing long-term cardiac complications.

Keywords:
cardiac lymphomacase reportdiffuse myocardial infiltrationsecondary heart lymphoma

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