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Host-microbe-cancer interactions on-a-chip.

Mauricio G C Sousa1,2,3, Danielle S K Brasino4, Madeline Krieger2

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Tumor microbiota influences cancer development and treatment. Tumor-on-a-chip models offer a promising in vitro approach to study these complex host-microbe interactions for improved cancer therapies.

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host-microbesmicrobesmicrofluidic devicestissue engineeringtumor on-a-chip

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Area of Science:

  • Oncology
  • Microbiology
  • Bioengineering

Background:

  • The tumor microbiota plays a critical role in cancer progression and therapeutic resistance.
  • Studying the complex interactions within the tumor microenvironment is challenging for traditional in vitro and in vivo models.

Purpose of the Study:

  • To review recent advancements and challenges in engineering tumor-on-a-chip systems.
  • To explore the application of these models in studying host-microbiota and tumor interactions.
  • To highlight the potential for developing novel cancer therapies.

Main Methods:

  • Utilizing microfluidic platforms to create tumor-on-a-chip models.
  • Mimicking key features of the tumor microenvironment, including fluid flow, extracellular matrix, and multicellular communication.
  • Engineering host-microbiota and tumor interactions within these controlled systems.

Main Results:

  • Tumor-on-a-chip models successfully replicate critical aspects of the native tumor microenvironment.
  • These platforms enable the study of complex microbe-tumor-immune cell interactions in vitro.
  • Progress has been made in engineering these intricate biological systems.

Conclusions:

  • Tumor-on-a-chip models are valuable tools for investigating tumor microbiota and its role in cancer.
  • Overcoming engineering challenges will provide deeper insights into tumor-microbe interactions.
  • These models hold significant potential for advancing the development of effective cancer therapies.