Calciphylaxis Penile Lesion: An Unusual Complication of End-Stage Renal Disease

Calciphylaxis is a rare disease that usually affects patients with end-stage renal disease (ESRD), also known as uremic calcific arteriolopathy. Calciphylaxis typically presents as an extremely painful skin nodule that progresses to ulcerated and frequently gangrenous lesions. Diagnosis can be difficult and treatment relies on a multidisciplinary approach to care. The following case describes a medically complex 37-year-old male patient with a painful penile calciphylaxis lesion. Calciphylaxis is a complex systemic disease that is difficult to diagnose. We highlighted in this case the importance of having a high index of suspicion in ESRD patients who present with a painful penile lesion.