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The association between constipation and anxiety: a cross-sectional study and Mendelian randomization analysis
Yingxuan Huang1, Yubin Wang1, Boming Xu1
1Department of Gastroenterology, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, Fujian, China.
Frontiers in Psychiatry
|April 15, 2025
Summary
Constipation is linked to anxiety in US adults, but this study found no direct cause. Addressing anxiety may help manage constipation symptoms.
Area of Science:
- Gastroenterology and Psychiatry
- Public Health Research
Background:
- The connection between constipation and anxiety is not well understood.
- This study addresses this gap by examining their relationship in a large US adult population.
Purpose of the Study:
- To investigate the association between constipation and anxiety.
- To explore potential causal links using genetic data.
Main Methods:
- Cross-sectional analysis of 9,126 adults from the National Health and Nutrition Examination Survey (NHANES) 2007-2010.
- Assessed constipation and anxiety using standardized instruments.
- Employed multivariable logistic regression and Mendelian randomization (MR) with genetic data.
Main Results:
- 3.6% of participants reported constipation; 26.6% reported anxiety.
- Anxiety prevalence was higher in those with constipation (41.4% vs. 26.0%).
- Constipation remained independently associated with anxiety (aOR 1.33, P=0.038), but MR showed no causal link.
Conclusions:
- A significant association exists between constipation and anxiety in US adults.
- The association is robust, but causality is not supported by genetic data.
- Clinicians should consider anxiety in constipation management.
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