Biopsychosocial needs of leukemic children - A systematic review

Kannan Kasinathan1, Rajamanickam Rajkumar2, Shankar Shanmugam Rajendran3

  • 1Research Scholar, Meenakshi Academy of Higher Education & Research(DU), Chennai & Department of Child Health Nursing, College of Nursing, Madras Medical College, Chennai , India.

Bioinformation
|April 15, 2025
PubMed

Insights

Pediatric leukemia survival is high, but early detection and post-treatment psychosocial support need improvement. Comprehensive care addressing medical, emotional, and social needs is vital for children with leukemia.

Area of Science:

  • Pediatric Oncology
  • Childhood Cancer Research
  • Hematology

Background:

  • Leukemia, including Acute Lymphoblastic Leukaemia (ALL) and Acute Myeloblastic Leukaemia (AML), is a significant cause of mortality in children.
  • While survival rates have improved to 80-90% due to advanced treatments, early detection remains a challenge, often relying on non-standardized methods.
  • Adherence to early recognition guidelines is crucial for timely diagnosis and intervention.

Purpose of the Study:

  • To systematically review the biopsychosocial needs of children diagnosed with leukemia.
  • To identify gaps in post-treatment care and evaluate the impact on mental health, emotional well-being, and quality of life.
  • To emphasize the need for standardized assessment methods and tailored interventions.

Main Methods:

  • A systematic review was conducted adhering to the PRISMA guidelines.
  • The review focused on literature concerning the biopsychosocial aspects of pediatric leukemia.
  • Data extraction and synthesis were performed to identify key findings regarding patient needs.

Main Results:

  • Significant gaps were identified in post-treatment care for pediatric leukemia patients.
  • Parent education emerged as a critical factor in managing the challenges faced by children.
  • The review highlighted the necessity of integrated approaches to manage psychosocial and emotional difficulties.

Conclusions:

  • Tailored interventions addressing medical, emotional, and social needs are essential for enhancing symptom control and quality of life in children with leukemia.
  • Improved adherence to early recognition guidelines and standardized assessment methods are required.
  • Further research is needed to develop and validate comprehensive care strategies for pediatric leukemia survivors.

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
263
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.1K
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
732
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.1K