Impact of the COVID-19 pandemic on care delivery, follow-up and outcomes in chronic myeloid leukemia patients: An observational cohort study
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View abstract on PubMed
Summary
This summary is machine-generated.The COVID-19 pandemic disrupted care for chronic myeloid leukemia (CML) patients, leading to significant loss of follow-up and poor treatment outcomes. Many patients experienced no hematological response or progressed to CML blast crisis.
Area Of Science
- Hematology
- Oncology
- Epidemiology
Background
- Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by a chronic phase.
- Disruptions in healthcare delivery, particularly during the COVID-19 pandemic, may impact CML patient outcomes.
- Understanding treatment adherence and follow-up is crucial for managing CML.
Purpose Of The Study
- To evaluate the impact of care delivery and loss of follow-up during the COVID-19 pandemic on outcomes in chronic myeloid leukemia (CML) patients.
- To analyze treatment adherence and progression in a cohort of CML patients.
- To identify factors contributing to adverse outcomes in CML management.
Main Methods
- Retrospective and prospective data retrieval from treated CML patients.
- Utilized questionnaires for patient history collection.
- Analyzed bone marrow slides (Giemsa stain) and performed multi-color flow cytometry for blast crisis evaluation.
Main Results
- A total of 961 new CML cases were analyzed, with ages ranging from 21 to 78 years.
- Loss of follow-up was predominantly observed during and after the COVID-19 pandemic, often due to non-compliance.
- Approximately 53% of cases showed no hematological response, and 34% transformed into a CML blast crisis phase.
Conclusions
- The COVID-19 pandemic significantly impacted CML patient care, leading to increased loss of follow-up and non-compliance.
- Delayed or interrupted treatment adherence is associated with poor hematological response and disease progression in CML.
- Effective strategies are needed to ensure continuous care and treatment adherence for CML patients, especially during public health crises.
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