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Enterococcal Endocarditis: Prospective Data from the Iranian Registry of Infective Endocarditis
Pardis Moradnejad1, Majid Maleki2, Sara Lotfian1
1Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
ARYA Atherosclerosis
|April 15, 2025
Summary
Enterococcal endocarditis presents serious complications and a high mortality rate. Further research into effective antibiotic treatments is crucial for managing this infection.
Area of Science:
- Infectious Diseases
- Cardiology
- Microbiology
Background:
- Enterococci cause 5-18% of infective endocarditis (IE) cases.
- Understanding enterococcal endocarditis is vital due to its significant impact.
Purpose of the Study:
- To analyze demographic data, predisposing factors, clinical presentations, complications, and echocardiographic findings in enterococcal endocarditis.
- To identify key characteristics of patients with enterococcal IE.
Main Methods:
- Adult patients diagnosed with IE (modified Duke criteria) were enrolled in the Iranian Registry of Infective Endocarditis since 2006.
- Demographic, clinical, laboratory, and echocardiographic data of patients with enterococcal IE were assessed.
Main Results:
- Enterococci were identified in 60 out of 731 endocarditis cases (8.2%).
- Prosthetic valve (46.7%) and prior endocarditis (20%) were common predisposing factors.
- High rates of vegetation (88.3%), heart failure (25%), CNS complications (18%), and a 20% mortality rate were observed.
Conclusions:
- Enterococcal endocarditis is associated with severe complications and high mortality, potentially due to antibiotic resistance.
- Further studies are needed to develop more effective and individualized antibiotic therapies for enterococcal endocarditis.
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