Related Experiment Video
Updated: May 13, 2025
Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
Exploring Clinical and Imaging Differences in COVID-19: an Observational Approach to the IFITM3 rs12252 Polymorphism
Adriana Mitrea1,2, Anca-Florentina Mitroi3,4, Cristian Opariuc-Dan5
1Doctoral School of Medicine, "Ovidius" University of Constanta, Constanta, Romania.
Purpose:
The severity of COVID-19 infections varies among individuals, prompting research into factors that may influence outcomes. Numerous studies have investigated the conditions that influence the intensity of illness caused by COVID-19. These factors include the Interferon-Induced Transmembrane Protein 3 (IFITM3) rs12252 polymorphism. We investigate whether the polymorphism rs12252 plays a role within our population and observe the differences in other parameters between the mild and severe forms of the disease.
Patients And Methods:
The observational study examining the IFTIM3 rs12252 polymorphism based on the level of COVID-19 severity and differences between inflammatory markers. The study included 51 participants, with 31 severe and 20 mild cases.
Results:
The average age of participants was 54 years, and 16.1% of patients with severe symptoms were diagnosed with the AG genotype. Patients showing serious symptoms had significantly higher ESR, CRP, Fibrinogen, LDH, and D-dimer levels than those with mild symptoms.
Conclusion:
This study discovered a notable correlation between the G allele of IFITM3 rs12252, inflammatory markers, CT scan score, and COVID-19 severity.
