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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
Published on: April 10, 2018
Long non-coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application
Ellen T Tran1, Ruchi A Patel1, Amogh Chariyamane1
1Department of Pathology, Saint Louis University, MO, USA.
Abstract:
Head and neck squamous cell carcinoma (HNSCC) is a major global health burden, often associated with poor prognosis and limited therapeutic options. Long non-coding RNAs (lncRNAs), a diverse group of non-coding RNA molecules > 200 nucleotides in length, have emerged as critical regulators in the pathogenesis of HNSCC. This review summarizes the mechanisms through which certain lncRNAs regulate chromatin modification, mRNA splicing, and interactions with RNA-binding proteins and contribute to the development and progression of HNSCC. Interaction of lncRNAs with key oncogenic pathways, such as PI3K/AKT and Wnt/β-catenin, highlights their importance in tumor progression. The role of lncRNAs, such as ELDR, MALAT1, NEAT1, HOTAIR, and UCA1, which promote cell proliferation, metastasis, immune evasion, and therapy resistance is discussed. Moreover, several lncRNAs are being evaluated in clinical trials for their potential as biomarkers, reflecting their clinical significance. We further address the challenges and opportunities for targeting lncRNA therapeutically, highlighting the promise of lncRNA-based interventions for personalized cancer treatment. Gaining insight into the function of lncRNAs in HNSCC could pave the way for novel therapeutic strategies to potentially improve patient outcomes.
Insights
Long non-coding RNAs (lncRNAs) are key regulators in head and neck squamous cell carcinoma (HNSCC) development. Targeting lncRNAs offers promising personalized treatment strategies for HNSCC patients.
Area of Science:
- Molecular Biology
- Oncology
- Genetics
Background:
- Head and neck squamous cell carcinoma (HNSCC) presents a significant global health challenge with poor prognoses.
- Long non-coding RNAs (lncRNAs) are increasingly recognized as crucial players in HNSCC pathogenesis.
Purpose of the Study:
- To review the regulatory mechanisms of lncRNAs in HNSCC development and progression.
- To highlight the role of specific lncRNAs in oncogenic pathways and clinical potential.
Main Methods:
- Literature review of studies investigating lncRNA function in HNSCC.
- Analysis of lncRNA interactions with chromatin modification, RNA-binding proteins, and oncogenic signaling pathways.
- Summary of clinical relevance and therapeutic targeting strategies for lncRNAs.
Main Results:
- lncRNAs regulate chromatin modification, mRNA splicing, and protein interactions, driving HNSCC.
- Specific lncRNAs (e.g., MALAT1, HOTAIR) promote proliferation, metastasis, immune evasion, and therapy resistance.
- Several lncRNAs show potential as biomarkers and therapeutic targets in clinical trials.
Conclusions:
- lncRNAs are critical regulators in HNSCC, influencing tumor progression and patient outcomes.
- Targeting lncRNAs presents a promising avenue for developing novel, personalized therapeutic strategies for HNSCC.
- Further research into lncRNA function can lead to improved treatment outcomes for HNSCC patients.
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