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Updated: May 13, 2025

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C-Ring Aromatized Abietane Diterpenoids From Lycopus lucidus
Xiao-Qiao Yang1,2, Ni Zhang1,2, Hanfei Liu1,2
1State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang, China.
Abstract:
The phytochemical research of the extract of Lycopus lucidus led to 12 aromatic C-ring abietane diterpenoids (1-12), including three new structures (1-3) obtained. The structures including absolute configurations of the new compounds were elucidated via high-resolution electrospray ionization mass spectrometry and nuclear magnetic resonance, combined with the electronic circular dichroism calculations. Among them, compound 1 is a rare 17-norditerpenoid, and compound 2 is a 19-norditerpenoid. Moreover, compound 3 is a rearranged 18(4→3)-abeo-abietane diterpenoid. The bioassay results showed that new compound 3 exhibited potential cytotoxicity on HEL cells, with a half-maximal inhibitory concentration (IC50) value of 14.59 ± 0.55 µM. Besides, compound 9 showed remarkable inhibitory activities against HEL cells, with the IC50 value of 0.93 ± 0.11 µM (stronger than that of the positive control, doxorubicin, IC50 = 0.95 ± 0.12 µM). Furthermore, the flow cytometry revealed that compound 9 exerts an anti-tumor effect and should be related to inducing HEL cell apoptosis.
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