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Related Experiment Video

Updated: May 13, 2025

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

Published on: December 3, 2020

Expression, Function, and Regulation of ABCG2 on the Intestinal Epithelial Barrier Permeability.

Ping Shi¹, Lianhua Tang¹, Fei Yin^1,2

¹College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, People's Republic of China.

Current Drug Metabolism

|April 15, 2025

Summary

Human breast cancer resistance protein (BCRP, ABCG2) in the intestine limits xenobiotic absorption and influences drug response. Its function is key to intestinal barrier integrity and drug disposition.

Keywords:

ATP-binding cassette (ABC) efflux transporter 2 (ABCG2)drug transport gene symbol intestinal barrier dysfunction intestinal epithelial permeability systemic circulation.

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Last Updated: May 13, 2025

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

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Published on: December 3, 2020

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Investigating Intestinal Barrier Breakdown in Living Organoids

Investigating Intestinal Barrier Breakdown in Living Organoids

Published on: March 26, 2020

Area of Science:

Pharmacology
Gastroenterology
Molecular Biology

Background:

Human breast cancer resistance protein (BCRP, ABCG2) is an ATP-binding cassette efflux transporter highly expressed in the intestinal epithelium.
The intestinal epithelial monolayer serves as a critical barrier between the body and the external environment.
Intestinal ABCG2 significantly impacts the absorption, distribution, and elimination of xenobiotics and endogenous molecules.

Purpose of the Study:

To review the role of intestinal ABCG2 in drug transport.
To summarize ABCG2's involvement in intestinal urate excretion.
To discuss ABCG2's contribution to intestinal barrier dysfunction and permeability changes in human intestinal disorders.

Main Methods:

Literature review of existing research on ABCG2 in the intestinal epithelium.
Analysis of studies investigating ABCG2's role in xenobiotic absorption and drug disposition.
Examination of research on ABCG2's impact on intestinal barrier function and disease.

Main Results:

Intestinal ABCG2 limits the absorption of its substrates in the small intestine.
Changes in ABCG2 expression and activity affect drug response and side effects.
ABCG2 plays a role in intestinal urate excretion and barrier dysfunction.

Conclusions:

Intestinal ABCG2 is a critical determinant of drug absorption and disposition.
ABCG2 function influences intestinal barrier integrity and permeability.
Dysregulation of intestinal ABCG2 is implicated in various human intestinal disorders and impacts therapeutic outcomes.