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A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions
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Ultra-Stable Gold Nanoparticles with Tunable Surface Characteristics.

Jing Wang1, Yanbao Xin2, Dazhi Chen1

  • 1State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Qianjin Street No. 2699, Changchun, 130012, P.R. China.

Angewandte Chemie (International Ed. in English)
|April 15, 2025
PubMed
Summary

Researchers developed a novel method to coat gold nanoparticles (Au NPs) with a stable polymer shell, enhancing their biocompatibility and stability for biomedical uses. This improves circulation and tumor targeting in vivo.

Keywords:
BiocompatibilityIn situ polymerizationLong circulationStability

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Area of Science:

  • Nanomaterials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Gold nanoparticles (Au NPs) offer unique properties for biomedical applications.
  • Colloidal Au NPs exhibit thermodynamic instability and poor biocompatibility in physiological settings due to high surface energy.

Purpose of the Study:

  • To develop an ultra-stable core-shell structure for Au NPs.
  • To enhance the stability and biocompatibility of Au NPs in biological environments.
  • To enable tailored surface modification of Au NPs for biomedical applications.

Main Methods:

  • In situ polymerization was employed to create a 3D polymer shell around Au NPs.
  • Monomer selection was utilized to precisely tailor the surface characteristics of the polymer shell.
  • The stability and biocompatibility of the coated Au NPs were evaluated in complex biological environments.

Main Results:

  • An ultra-stable core-shell structure of polymer-coated Au NPs was successfully created.
  • The polymer shell significantly improved the stability and biocompatibility of Au NPs in physiological environments.
  • Tailored surface properties allowed for prolonged circulation and enhanced tumor targeting in mice.

Conclusions:

  • The novel in situ polymerization strategy provides an ultra-stable, aqueous-based, and biocompatible polymer shell for Au NPs.
  • This approach offers a versatile platform for surface modification of gold nanomaterials for advanced biomedical applications.
  • The enhanced properties of coated Au NPs hold significant promise for in vivo applications, including drug delivery and diagnostics.