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Uveitis in child treated for acute myeloblastic leukemia: Do not overlook poststreptococcal inflammation
Philippe Gardeton1, Inés Chabbi2, Margaux Camuset1
1Pediatric Oncology and Hematology, Nantes University Hospital, Nantes, France.
Insights
Post-Streptococcus mitis uveitis is a rare immune complication. This case highlights its potential misdiagnosis in leukemia patients undergoing chemotherapy, emphasizing the need for consideration despite neutropenia.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Hematology
Background:
- Post-streptococcal uveitis is a known immune complication of streptococcal infections.
- Acute myeloblastic leukemia (AML) treatment involves chemotherapy, which can cause immunosuppression and febrile neutropenia.
- Cytarabine is a common chemotherapeutic agent used in AML treatment.
Abstract:
IntroductionPoststreptococcal uveitis is among the immune complications following strep infections.Case descriptionA patient treated for acute myeloblastic leukemia presented with febrile neutropenia 22 days after consolidation chemotherapy including cytarabine. Diagnosed with Streptococcus mitis bacteremia, she subsequently presented with uveitis in her right eye, linked to the previous infection through positive anti-streptolysin O and negative microbiological test results. Topical treatment resulted in complete recovery.ConclusionThis unprecedented presentation of post-S. mitis uveitis reveals the potential for misdiagnosis of ocular manifestations after cytarabine treatment. Furthermore, neutropenia and profound lymphopenia should not prevent both the ophthalmologist and the hematologist from considering poststreptococcal immune complications.
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