Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Regulation01:37

Neural Regulation

39.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.0K
Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

197
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
197
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

207
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
207
Enteric Nervous System: Regulation of GI Motor Activity01:11

Enteric Nervous System: Regulation of GI Motor Activity

246
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
246
Nerve Supply of the GI Tract01:27

Nerve Supply of the GI Tract

736
The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
736
Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

212
Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
212

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From bench to bedside: pancreatic juice as a platform for biomarker discovery in pancreatic disease.

The Korean journal of internal medicine·2026
Same author

Postural Orthostatic Tachycardia Syndrome: A State-of-the-Art Review.

Heart, lung & circulation·2026
Same author

Proceeding with liver transplantation in acute non-necrotizing pancreatitis: A 10-year propensity-matched cohort study.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]·2025
Same author

Impact of artificial intelligence-assisted colonoscopy on gastroenterology fellow performance: a pragmatic randomized controlled trial.

Gastrointestinal endoscopy·2025
Same author

Correction To: The Neuroimmune Axis in Gastrointestinal Disorders- An Underrecognized Problem.

Current gastroenterology reports·2025
Same author

A geological timescale for bacterial evolution and oxygen adaptation.

Science (New York, N.Y.)·2025

Related Experiment Video

Updated: May 13, 2025

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
09:18

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

2.4K

The Neuroimmune Axis in Gastrointestinal Disorders - An Underrecognized Problem.

Laura A Pace1,2, Niwen Kong3, Mohamed I Itani4

  • 1Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Stanford, CA, USA. lapace@stanford.edu.

Current Gastroenterology Reports
|April 15, 2025
PubMed
Summary

This review introduces the neuroimmune axis in the gut, highlighting its role in chronic diseases. Recent advances reveal complex interactions influencing health and illness.

More Related Videos

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
09:04

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

47.1K
In Vitro Recording of Mesenteric Afferent Nerve Activity in Mouse Jejunal and Colonic Segments
10:32

In Vitro Recording of Mesenteric Afferent Nerve Activity in Mouse Jejunal and Colonic Segments

Published on: October 25, 2016

11.4K

Related Experiment Videos

Last Updated: May 13, 2025

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
09:18

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

2.4K
DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
09:04

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

47.1K
In Vitro Recording of Mesenteric Afferent Nerve Activity in Mouse Jejunal and Colonic Segments
10:32

In Vitro Recording of Mesenteric Afferent Nerve Activity in Mouse Jejunal and Colonic Segments

Published on: October 25, 2016

11.4K

Area of Science:

  • Neuroimmunology
  • Gastroenterology
  • Chronic Multisystem Disorders

Background:

  • The neuroimmune axis integrates nervous, immune, and endocrine systems.
  • The gastrointestinal system is a key site for neuroimmune interactions.
  • Dysregulation contributes to chronic multisystem disorders.

Purpose of the Study:

  • Introduce the neuroimmune axis focusing on the gastrointestinal system.
  • Discuss its role in chronic multisystem disorders.
  • Highlight emerging diagnostic and therapeutic tools.

Main Methods:

  • Literature review of recent breakthroughs.
  • Synthesis of current understanding of neuroimmune interactions.
  • Overview of novel diagnostic and therapeutic strategies.

Main Results:

  • Significant advances in understanding gut neuroimmune axis.
  • Interactions involve nervous, immune, endocrine systems, ECM, and microbiota.
  • These interactions modulate gastrointestinal health and disease.

Conclusions:

  • The neuroimmune axis is crucial for gastrointestinal health.
  • Understanding these interactions is key for treating chronic diseases.
  • Emerging tools offer new diagnostic and therapeutic avenues.