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The Neuroimmune Axis in Gastrointestinal Disorders - An Underrecognized Problem
Laura A Pace1,2, Niwen Kong3, Mohamed I Itani4
1Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Stanford, CA, USA. lapace@stanford.edu.
Current Gastroenterology Reports
|April 15, 2025
Summary
This review introduces the neuroimmune axis in the gut, highlighting its role in chronic diseases. Recent advances reveal complex interactions influencing health and illness.
Area of Science:
- Neuroimmunology
- Gastroenterology
- Chronic Multisystem Disorders
Background:
- The neuroimmune axis integrates nervous, immune, and endocrine systems.
- The gastrointestinal system is a key site for neuroimmune interactions.
- Dysregulation contributes to chronic multisystem disorders.
Purpose of the Study:
- Introduce the neuroimmune axis focusing on the gastrointestinal system.
- Discuss its role in chronic multisystem disorders.
- Highlight emerging diagnostic and therapeutic tools.
Main Methods:
- Literature review of recent breakthroughs.
- Synthesis of current understanding of neuroimmune interactions.
- Overview of novel diagnostic and therapeutic strategies.
Main Results:
- Significant advances in understanding gut neuroimmune axis.
- Interactions involve nervous, immune, endocrine systems, ECM, and microbiota.
- These interactions modulate gastrointestinal health and disease.
Conclusions:
- The neuroimmune axis is crucial for gastrointestinal health.
- Understanding these interactions is key for treating chronic diseases.
- Emerging tools offer new diagnostic and therapeutic avenues.
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