Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Uncertainty factors and interindividual variation.

E J Calabrese

    Regulatory Toxicology and Pharmacology : RTP
    |June 1, 1985
    PubMed
    Summary

    Human responses to environmental agents vary significantly, often exceeding a tenfold difference. Most individuals, however, show responses within this range, impacting regulatory toxicology assessments.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy.

    Mechanisms of ageing and development·2022
    Same author

    Radiotherapy treatment of human inflammatory diseases and conditions: Optimal dose.

    Human & experimental toxicology·2019
    Same author

    Funding trends in hormetic research.

    Human & experimental toxicology·2019
    Same author

    Originator of the hormesis concept: Rudolf Virchow or Hugo Schulz.

    Human & experimental toxicology·2017
    Same author

    Hormesis, cellular stress response, and redox homeostasis in autism spectrum disorders.

    Journal of neuroscience research·2016
    Same author

    Adaptive preconditioning in neurological diseases - therapeutic insights from proteostatic perturbations.

    Brain research·2016

    Area of Science:

    • Toxicology
    • Environmental Health
    • Human Genetics

    Background:

    • Individual susceptibility to environmental agents exhibits wide variability.
    • Understanding this variation is crucial for accurate risk assessment.
    • Current toxicological evaluations often rely on generalized safety factors.

    Purpose of the Study:

    • To analyze the extent of human variation in response to environmental agents.
    • To evaluate the implications of observed variation on regulatory toxicology.
    • To discuss the adequacy of current uncertainty factors.

    Main Methods:

    • Review of existing toxicological data on human responses to environmental agents.
    • Quantitative analysis of response variability across populations.
    • Comparative analysis of observed variation versus established uncertainty factors.

    Main Results:

    • Human variation in response to environmental agents frequently exceeds a factor of 10.
    • In some cases, variation can reach several orders of magnitude.
    • The majority of studied individuals exhibit responses within a factor of 10.

    Conclusions:

    • Observed human variability necessitates a re-evaluation of uncertainty factors in regulatory toxicology.
    • Current uncertainty factors may not fully capture the spectrum of individual responses.
    • Further research is needed to refine risk assessment strategies based on population variability.

    Related Experiment Videos