Maternal Tmprss6 is required for hepcidin suppression and fetal health

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Katherine Louise Fielding1,2,3, Cavan Bennett1,2, Anne Pettikiriarachchi1

  • 1Infection and Global Health Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

Blood
|April 15, 2025
PubMed

The antenatal role of the hepcidin-regulating protease Tmprss6 has never been elucidated because knockout dams are infertile. Using an in vivo knockdown approach, we confirm Tmprsss6 is critical for hepcidin suppression in pregnancy, and Tmprss6 inhibition drives deleterious fetal outcomes.

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