Forkhead Box M1 isoform 3 overexpression is associated with malignancy grade in adult-type diffuse gliomas
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View abstract on PubMed
Summary
This summary is machine-generated.Overexpression of Forkhead Box M1 isoform 3 (FOXM1*3) correlates with higher glioma malignancy. This finding suggests FOXM1*3 can aid in accurately grading brain tumors, especially grade 3 gliomas.
Area Of Science
- Neuro-oncology
- Molecular Biology
- Cancer Research
Background
- Forkhead Box M1 (FOXM1) is a transcription factor overexpressed in various cancers.
- The active FOXM1 isoform 3 (FOXM1*3) is linked to cancer progression.
- The role of FOXM1*3 in brain glioma malignancy is not well understood.
Purpose Of The Study
- To evaluate the association between FOXM1*3 overexpression and the degree of malignancy in adult-type diffuse gliomas (ATDGs).
Main Methods
- Prospective study of 81 ATDG samples and 10 healthy controls.
- Quantification of FOXM1*3 transcript using qPCR.
- Tumor classification by malignancy grade and cell lineage, with survival analysis.
Main Results
- Significant differences in FOXM1*3 expression between controls and gliomas (p < 0.001).
- FOXM1*3 expression varied significantly across glioma grades 2, 3, and 4 (p < 0.005-0.0001).
- Expression differences were noted between grade 2 and 3 astrocytomas and glioblastomas.
Conclusions
- FOXM1*3 overexpression can help resolve intra-observer discrepancies in glioma grading, particularly for grade 3.
- FOXM1*3 serves as a potential supplementary tool for glioma malignancy assessment.
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