Pullulan as a sustained release carrier for ocular drug delivery: a review

Pullulan, an exopolysaccharide, obtained from the fungus Aureobasidium pullulans, is a non-ionic, hydrophilic, biodegradable, biocompatible, and tolerogenic polymers that is used for the formulation of bioconjugates in the therapeutic delivery to target different cells and tissues. It is known to possess outstanding film-casting qualities and can produce a clear and biodegradable film. Furthermore, appropriate derivatizing pullulan provides active surfaces that facilitate binding with active pharmaceutical ingredients to the polymer backbone to produce micro/nanoparticulate systems for controlled or sustained drug release. Ophthalmic problems like glaucoma, age-related macular degeneration, and cataracts are very prevalent across the globe, and their treatment options mainly include conventional topical solutions and gels, which possess very low drug-contact time and poor bioavailability, leading to frequent dosing and patient incompliance. Sustained release dosage forms like ocuserts, ocular films, and in-situ gels can help in achieving the intended therapeutic outcomes for an extended duration by minimizing the number of doses. Here, we present a comprehensive critical review of the utilization and application of pullulan, together with its derivatives, to combat problems with ocular medication administration. This article also provides insight for further research on this topic to utilize its advantages to the fullest in the future for improved delivery of therapeutics in the treatment of ocular disorders.