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Published on: November 30, 2022
Copper-Catalyzed C-B(sp3) Bond Formation through the Intermediacy of Cu-B(sp3) Complex
Zhanqiang Ye1, Chun Yin Kwok1, Sze Lam Lam1
1Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, SAR 999077, P. R. China.
Abstract:
The vast majority of transition metal (TM) catalyzed borylative transformations rely on TM-B(sp2) complexes. Contrastingly, the chemistry of TM-B(sp3) species and their potential in catalytic borylation remain surprisingly underdeveloped, due probably to the lack of suitable boron(sp3) reagents. Herein, we employ our recently developed sp2-sp3 diboron reagent to successfully enable a copper-catalyzed hydroboration of allenes for C-B(sp3) bond formation. A comprehensive mechanistic study, including the isolation and structural characterization of a Cu-B(sp3) complex, substantiates the presence of a Cu-B(sp3) intermediate in the catalytic cycle.
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