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Related Experiment Video

Updated: May 13, 2025

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

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Published on: April 12, 2024

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A model of basement membrane-related regulators for prediction of prognoses in esophageal cancer and verification in

Lang Xu1,2,3, Bingna Wang1,4, Chen Wang1

  • 1The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, 511400, China.

BMC Cancer
|April 15, 2025
PubMed
Summary

Researchers identified a six-gene signature from basement membrane components to predict esophageal carcinoma survival. This model aids in prognostic stratification and suggests potential therapeutic targets for cancer progression.

Keywords:
Basement membraneCell migrationEsophageal cancerGene knock-downPrognostic gene markers

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Basement membrane components are implicated in cancer metastasis, but their specific roles in esophageal carcinoma are not well understood.
  • Esophageal carcinoma is a significant global health concern with a need for improved prognostic markers.

Purpose of the Study:

  • To identify basement membrane-related prognostic gene signatures in esophageal carcinoma.
  • To develop a predictive model for overall survival using these signatures.
  • To explore the functional roles of identified genes in tumor progression.

Main Methods:

  • Differential gene expression profiling and Least Absolute Shrinkage and Selection Operator (LASSO) regression on 152 esophageal cancer and 11 normal tissue samples.
  • Nomogram modeling integrating a six-gene panel (LAMC2, GPC2, AGRN, ITGA3, LAMA3, LOXL4) with clinical features.
  • Immunohistochemical assays and in vitro experiments (gene knockdown/suppression) in esophageal squamous carcinoma cells.

Main Results:

  • A robust six-gene prognostic signature was identified, demonstrating significant predictive capacity for overall survival.
  • Computational analyses revealed distinct tumor microenvironment immune cell profiles and chemotherapeutic drug sensitivities across risk groups.
  • Experimental validation confirmed increased expression of these genes in tumor tissues and elucidated their opposing roles in cell migration and proliferation.

Conclusions:

  • A novel basement membrane-derived risk model for esophageal carcinoma has been established, enhancing prognostic stratification.
  • The identified genes play crucial roles in regulating tumor progression, offering potential therapeutic targets.
  • This study provides valuable insights into the molecular mechanisms driving esophageal carcinoma metastasis and progression.