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miR-126: a bridge between cancer and exercise.
Zhengqiong Liu1, Shanbin Ke1, Yuwen Wan2
1College of Education, Jiangxi Institute of Applied Science and Technology, Nanchang, 330100, China.
Cancer Cell International
|April 15, 2025
Summary
Exercise increases microRNA 126 (miR-126) levels, promoting cardiovascular health and potentially slowing cancer growth. This microRNA plays a dual role in cancer, acting as both a suppressor and enhancer.
Area of Science:
- Molecular Biology
- Exercise Physiology
- Oncology
Background:
- MicroRNA miR-126 is crucial for endothelial cells and blood vessel integrity.
- Emerging research links miR-126 to the interplay between exercise and cancer.
- miR-126 influences cardiovascular well-being and metabolic control.
Purpose of the Study:
- To investigate how exercise modulates miR-126 expression.
- To explore the role of miR-126 in cardiovascular function.
- To elucidate the dual function of miR-126 in cancer progression and suppression.
Main Methods:
- Analysis of miR-126 expression changes in response to aerobic exercise (including HIIT) and resistance training.
- Review of molecular pathways affected by miR-126, including VEGF, HIF-1α, and EPC mobilization.
- Examination of miR-126's involvement in cancer-related pathways (PI3K/Akt, ERK/MAPK, EMT) and its association with cancer outcomes.
Main Results:
- Aerobic exercise, particularly HIIT, significantly elevates miR-126 levels, enhancing angiogenesis, endothelial repair, and vascular function.
- Resistance training does not substantially alter miR-126 levels.
- Lower miR-126 levels correlate with adverse outcomes and advanced stages across various cancers (glioblastoma, CRC, ovarian, esophageal, gastric, prostate).
Conclusions:
- Exercise-induced upregulation of miR-126 offers a potential therapeutic strategy for improving vascular health and inhibiting tumor growth.
- miR-126 acts as a context-dependent regulator in cancer, suppressing tumors via key signaling pathways.
- Further research is needed to fully understand miR-126's molecular mechanisms in exercise and cancer for targeted interventions.
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