Sex-Biased Admixture Followed by Isolation and Adaptive Evolution Shaped the Genomic and Blood Pressure Diversity of the LopNur People
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View abstract on PubMed
Summary
This summary is machine-generated.The LopNur people show a complex genetic history of admixture and isolation, with ancestry from East Asia, West Eurasia, Siberia, and South Asia. This study reveals adaptive evolution and sex-biased gene flow in this unique desert-dwelling ethnic group.
Area Of Science
- Population Genetics
- Human Evolutionary Studies
- Genomics
Background
- The LopNur people, an isolated ethnic group near the Taklamakan Desert, possess a poorly understood genetic makeup.
- Limited genetic research hinders knowledge of their ancestral origins and demographic history.
Purpose Of The Study
- To conduct the first whole-genome sequencing of LopNur individuals to investigate their genetic history and adaptive evolution.
- To understand the demographic processes shaping the LopNur gene pool in an isolated desert environment.
Main Methods
- Whole-genome sequencing of 164 LopNur individuals.
- Population genetic analyses to infer ancestry, admixture, and demographic history.
- Joint analysis of genomic data and blood pressure for adaptive evolution insights.
Main Results
- The LopNur exhibit complex admixture with ancestry from East Asia (~41.46%), West Eurasia (~26.43%), Siberia (~24.27%), and South Asia (~7.82%).
- Evidence of significant sex-biased admixture between Western males and Eastern females.
- Identification of potential genetic adaptations, including a USP35-GAB2 region linked to blood pressure and variants (rs7387065, rs2229437) associated with antihypertensive drug absorption.
Conclusions
- The LopNur gene pool is shaped by ancient admixture, long-term isolation, adaptive evolution, and sex-biased gene flow.
- This study provides crucial insights into the genetic history of an admixed and isolated population at the crossroads of East and West.
- Genetic findings offer potential links to physiological traits and drug responses relevant to the LopNur population.
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