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Related Experiment Video

Updated: May 13, 2025

Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis

Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis

Published on: April 16, 2019

Bacterial Autonomous Intelligent Microrobots for Biomedical Applications.

Haotian Chen^1,2, Yingze Li^2,3, Zhenguang Li²

¹Frontiers Science Center for Intelligent Autonomous Systems, Tongji University, Shanghai, China.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology

|April 16, 2025

Summary

Engineered bacteria act as intelligent microrobots for precise biomedical tasks. This review details their sensing, control, and future applications in precision medicine.

Keywords:

autonomous intelligence bacteria biomedical applications microrobots synthetic biology

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Last Updated: May 13, 2025

Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis

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Published on: April 16, 2019

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Published on: February 28, 2020

Remote Magnetic Actuation of Micrometric Probes for in situ 3D Mapping of Bacterial Biofilm Physical Properties

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Published on: May 2, 2014

Area of Science:

Biomedical Engineering
Synthetic Biology
Robotics

Background:

Micro/nanorobots offer remote diagnostics and therapeutics in medicine.
Achieving closed-loop control for biomedical micro/nanorobots remains a challenge.
Bacteria possess self-propulsion and intelligence, ideal for microrobot engineering.

Purpose of the Study:

To review sensing and control mechanisms of bacterial microrobots.
To highlight the engineering and applications of bacterial microrobots.
To forecast future directions for autonomous intelligent microrobots in precision medicine.

Main Methods:

Utilizing synthetic biology to engineer bacteria as microrobots.
Developing genetic toolboxes for sensors and response systems.
Designing control systems for complex physiological environments.

Main Results:

Bacterial microrobots can be equipped with sensors for signal response and memory.
Synthetic biology enables expanded capabilities for bacterial microrobots.
Accurate control systems are crucial for complex biomedical applications.

Conclusions:

Bacterial microrobots represent a promising platform for closed-loop biomedical control.
Engineering bacteria offers a viable path toward autonomous intelligent microrobots.
Future developments focus on precision medicine applications for bacterial microrobots.