Prognostic Value of SOX9, E-Cadherin, and KLF4 Expressions in Clear Cell Renal Carcinoma

Seyma Ozturk ¹, Selma Erdogan Duzcu ²

⁰Department of Pathology, Sanliurfa Training and Research Hospital, Sanliurfa, Turkiye.

Journal of the College of Physicians and Surgeons--Pakistan : Jcpsp +

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April 16, 2025

View abstract on PubMed

Summary

Stem cell factors SOX9 and KLF4, along with E-cadherin, are linked to unfavorable prognostic factors in clear cell renal cell carcinoma (ccRCC). These markers may help predict prognosis and treatment response in ccRCC patients.

Area Of Science

Oncology
Molecular Pathology
Cancer Biomarkers

Background

Clear cell renal cell carcinoma (ccRCC) is a significant health concern.
Identifying reliable prognostic markers is crucial for effective ccRCC management.
Stem cell-related factors play a role in cancer development and progression.

Purpose Of The Study

To investigate the immunohistochemical expression of SOX9 and KLF4 in ccRCC.
To determine the association of SOX9 and KLF4 expression with clinicopathological parameters and prognosis.
To evaluate the potential of SOX9, KLF4, and E-cadherin as biomarkers in ccRCC.

Main Methods

A descriptive study analyzed 92 ccRCC specimens from nephrectomies.
Immunohistochemical staining for SOX9, KLF4, and E-cadherin was performed.
Statistical analyses (Mann-Whitney U, Kruskal-Wallis) correlated marker expression with prognostic factors.

Main Results

SOX9, KLF4, and E-cadherin expression levels significantly correlated with high nuclear grade.
Overexpression of SOX9 was significantly associated with distant metastasis and advanced stage.
These findings highlight the link between these factors and aggressive tumor characteristics.

Conclusions

SOX9, E-cadherin, and KLF4 expression are associated with unfavorable prognostic factors in ccRCC.
These immunohistochemical markers show potential for predicting prognosis and guiding treatment decisions.
Further research can validate their role as predictive biomarkers in ccRCC.