Related Experiment Video

Updated: May 4, 2026

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

6.7K

The emerging roles and mechanisms of FAM83H‑AS1 in cancer: Pathophysiology and therapeutic implications (Review)

Jin-Long Shi1, Chen-Shi Lin2, Ming-Hui Gong3

  • 1Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434000, P.R. China.

Oncology Letters
|April 16, 2025
PubMed

Insights

Family with sequence similarity 83 member H-antisense RNA 1 (FAM83H-AS1) is an oncogenic long non-coding RNA that promotes cancer progression and may serve as a diagnostic and prognostic biomarker.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) regulate gene expression and are implicated in cancer progression, diagnosis, and prognosis.
  • Family with sequence similarity 83 member H-antisense RNA 1 (FAM83H-AS1) is an oncogenic lncRNA overexpressed in various malignancies.

Purpose of the Study:

  • To review the expression patterns of FAM83H-AS1 in cancer.
  • To elucidate the underlying mechanisms of FAM83H-AS1's oncogenic functions.
  • To explore the potential of FAM83H-AS1 as a clinical biomarker for cancer diagnosis and prognosis.

Main Methods:

  • Literature review of studies on FAM83H-AS1 in cancer.
  • Analysis of FAM83H-AS1 expression data in different cancer types.
  • Investigation of FAM83H-AS1's molecular interactions with microRNAs and signaling pathways.

Main Results:

  • FAM83H-AS1 expression is elevated in several types of cancer.
  • FAM83H-AS1 promotes cancer cell proliferation, inhibits apoptosis, enhances migration, and confers chemoresistance.
  • FAM83H-AS1 interacts with specific microRNAs (miR-136-5p, miR-545-3p, miR-15a, miR-10a-5p) and signaling pathways (Wnt/β-catenin, Notch receptor).

Conclusions:

  • FAM83H-AS1 plays a significant role in oncogenesis through various molecular mechanisms.
  • FAM83H-AS1 holds promise as a potential biomarker for cancer diagnosis and prognosis.
  • Further clinical studies are warranted to validate FAM83H-AS1's utility in cancer management.
Keywords:
biomarkercancerfamily with sequence similarity 83 member H-antisense RNA 1long non-coding RNAmicroRNA

More Related Videos

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

4.3K
Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer04:20

Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer

Published on: February 9, 2024

842

Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.6K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.3K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.0K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.2K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.9K