Related Experiment Video
Updated: Jun 27, 2026
Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma
Published on: September 3, 2021
Trends in nanomedicine for colorectal cancer treatment: Bibliometric and visualization analysis (2010-2024)
Yu-Ren Zhang1, Hui-Rong Zhu1, Hao-Ran Li1
1Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Background:
Recently, numerous studies have reported the application of nanomedicines in colorectal cancer treatment. However, no systematic bibliometric analysis has been conducted to examine the potential and mechanisms of action of nanomedicine in this context. Such an analysis may provide a comprehensive overview of the current research landscape, identify emerging trends, and highlight key areas for future investigation.
Aim:
To describe the current global research landscape on the application of nanomedicine in colorectal cancer treatment.
Methods:
The Web of Science Core Collection database was searched for literature published from January 1, 2010, to August 7, 2024, focusing on the application of nanomedicine in colorectal cancer treatment. Bibliometric analysis and visualization mapping of countries, institutions, authors, keywords, references of the relevant research literature were conducted using CiteSpace (6.2R6), VOSviewer (1.6.20), and bibliometrix (based on R 4.3.2).
Results:
A total of 3598 articles were included, with a rapid increase in publication volume starting from 2010. China published the most papers on this topic, followed by the United States and India. The United States emerged as the central country in this field, and the Egyptian Knowledge Bank and Chinese Academy of Sciences were the institutions with the highest number of publications. The Chinese Academy of Sciences exhibited the highest centrality. The most prolific author was Zhang Y, whereas Siegel RL was the most cited author, and Li Y had the highest H-index. The International Journal of Nanomedicine had the most publications and Biomaterials received the most citations. Keyword co-occurrence analysis identified 11837 keywords grouped into 13 clusters with 15 high-frequency highlighted keywords. The top three keyword clusters were "0 colorectal cancer", "1 drug delivery", and "2 delivery", with the top three keywords being "nanoparticles", "colorectal cancer", and "drug delivery".
Conclusion:
Research on nanomedicine for colorectal cancer has surged since 2010, focusing on "nanoparticles" and "drug delivery". Future studies should investigate nanomaterial stability and target-specific drug release.
Insights
Research on nanomedicine for colorectal cancer treatment has rapidly increased since 2010. Key focus areas include nanoparticles and drug delivery, with China leading publications.
Area of Science:
- Nanomedicine
- Oncology
- Biotechnology
Background:
- Nanomedicine applications in colorectal cancer treatment are increasingly reported.
- A systematic bibliometric analysis is needed to understand the research landscape and trends.
- This study provides a comprehensive overview of nanomedicine in colorectal cancer research.
Purpose of the Study:
- To analyze the global research landscape of nanomedicine in colorectal cancer treatment.
- To identify key trends, influential countries, institutions, and authors.
- To map the intellectual structure and emerging themes in this field.
Main Methods:
- Bibliometric analysis of 3598 articles from Web of Science (2010-2024).
- Visualization mapping using CiteSpace, VOSviewer, and bibliometrix.
- Analysis of countries, institutions, authors, keywords, and references.
Main Results:
- Publication volume surged from 2010, with China as the leading country.
- Chinese Academy of Sciences and United States showed high activity and centrality.
- Keywords like "nanoparticles" and "drug delivery" were prominent, indicating research focus.
Conclusions:
- Nanomedicine research for colorectal cancer has grown significantly since 2010.
- The field is characterized by a focus on nanoparticles and drug delivery systems.
- Future research should explore nanomaterial stability and targeted drug release mechanisms.
More Related Videos
Related Concept Videos
01:15Drugs that Stabilize Microtubules
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...
02:50Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...