Investigation of high-mobility group box 1 variants with lymph node status and colorectal cancer risk
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View abstract on PubMed
Summary
This summary is machine-generated.The high-mobility group box 1 (HMGB1) rs1412125 polymorphism is associated with an increased risk of colorectal cancer (CRC). This specific genetic variation may influence CRC susceptibility, particularly in certain demographic groups.
Area Of Science
- Genetics
- Oncology
- Molecular Biology
Background
- Nuclear homeostasis is crucial for cancer prevention.
- High-mobility group box 1 (HMGB1) may impact colorectal cancer (CRC) risk and prognosis.
- Investigating genetic variations in HMGB1 is important for understanding CRC development.
Purpose Of The Study
- To determine if HMGB1 polymorphisms affect the risk of developing colorectal cancer (CRC).
- To assess the association between HMGB1 polymorphisms and lymph node metastasis (LNM) in CRC patients.
Main Methods
- A case-control study involving 1003 CRC patients and 1303 cancer-free controls.
- Genotyping of HMGB1 single nucleotide polymorphisms (SNPs): rs1412125 T > C and rs1045411 C > T.
- Correlation analysis to evaluate the association between SNPs and CRC risk, and LNM.
Main Results
- The HMGB1 rs1412125 SNP was linked to an increased susceptibility to CRC.
- Subgroup analysis indicated that rs1412125 may increase CRC risk in individuals aged ≥ 61, non-drinkers, and those with a BMI < 24 kg/m².
- No significant association was found between HMGB1 rs1412125 and LNM, nor between rs1045411 and CRC risk or LNM.
Conclusions
- The HMGB1 rs1412125 polymorphism may be associated with an elevated risk of colorectal cancer.
- Further research is warranted to elucidate the role of HMGB1 rs1412125 in CRC pathogenesis.
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