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Precision treatment for human epidermal growth factor receptor 2-amplified advanced rectal cancer: A case report

Xia Xiao1, Qing-Wen Wang2, Zheng-Yang Zhou2

  • 1Department of Oncology, Wuxi No. 2 People's Hospital, Jiangnan University Medical Center, Wuxi 214002, Jiangsu Province, China.

World Journal of Gastrointestinal Oncology
|April 16, 2025
PubMed
Abstract

Insights

Immune checkpoint inhibitors (ICIs) combined with pyrotinib showed significant efficacy in a patient with HER2-amplified advanced rectal cancer resistant to standard treatments. This combination therapy, including chemotherapy, offers a promising approach for refractory cases.

Area of Science:

  • Oncology
  • Gastrointestinal Cancer Research
  • Molecular Targeted Therapy

Background:

  • Metastatic colorectal cancer (CRC) poses challenges due to treatment resistance.
  • Human epidermal growth factor receptor 2 (HER2) overexpression occurs in a subset of CRC patients, representing a therapeutic target.
  • Standard therapies may fail in patients with advanced or metastatic disease.
Keywords:
Case reportChemotherapyHuman epidermal growth factor receptor 2Programmed death 1PyrotinibRectal cancer

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