Using bioinformatics methods to elucidate fatty acid-binding protein 4 as a potential biomarker for colon adenocarcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Fatty acid-binding protein 4 (FABP4) is a promising biomarker for colon adenocarcinoma (COAD) screening and diagnosis. Its expression correlates with immune cell infiltration and aids in predicting patient survival.
Area Of Science
- Oncology
- Molecular Biology
- Biomarker Discovery
Background
- Colon adenocarcinoma (COAD) is a leading cause of cancer mortality.
- Fatty acid-binding protein 4 (FABP4) is implicated in cell adhesion and immune responses relevant to COAD development.
Purpose Of The Study
- To investigate FABP4 as a potential biomarker for COAD.
- To develop a predictive model for COAD patient survival.
Main Methods
- Analysis of FABP4 expression in 453 COAD and 41 normal tissues from TCGA.
- Immunohistochemistry validation.
- WGCNA and enrichment analyses for FABP4 function and immune infiltration.
- Development and validation of a prognostic nomogram using Cox analysis and GEO database.
Main Results
- FABP4 was significantly differentially expressed in COAD tissues.
- FABP4 expression positively correlated with immune cell infiltration.
- A nomogram integrating FABP4 risk scores and clinicopathological factors accurately predicted 1-, 3-, and 5-year survival (C-index = 0.786, validated C-index = 0.73).
Conclusions
- FABP4 serves as an effective biomarker for COAD screening and diagnosis.
- FABP4 aids in determining prognosis for COAD patients.
- The developed nomogram provides a valuable tool for predicting COAD patient survival.
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