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Updated: May 13, 2025

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
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Targeting Oncogenic Pathways: Advances in KRAS, CDK, EGFR, and PROTAC-Based Therapies

Robert B Kargbo1

  • 1Usona Institute, Fitchburg, Wisconsin 53711-5300, United States.

ACS Medicinal Chemistry Letters
|April 16, 2025
PubMed

Insights

This Patent Highlight details new small-molecule inhibitors targeting KRAS mutations and cyclin-dependent kinases (CDKs). These advancements offer potential new therapies for cancers like nonsmall cell lung cancer (NSCLC).

Area of Science:

  • Oncology
  • Medicinal Chemistry
  • Drug Discovery

Background:

  • Cancer progression is often driven by specific genetic mutations and dysregulated cellular pathways.
  • KRAS mutations and aberrant cyclin-dependent kinase (CDK) activity are key drivers in various cancers, including NSCLC, colorectal, and pancreatic cancers.

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