Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

19
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
19
Obesity01:24

Obesity

347
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
347
T Cell Types and Functions01:24

T Cell Types and Functions

633
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
633
Inflammatory Response01:28

Inflammatory Response

1.6K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.6K
Inflammation01:38

Inflammation

51.5K
Overview
51.5K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

7.2K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BATF-dependent Th17 cells act through the IL-23R pathway to promote prostate adenocarcinoma initiation and progression.

Journal of the National Cancer Institute·2024
Same author

A Novel Strategy to Model Age-Related Cancer for Elucidation of the Role of Th17 Inflammaging in Cancer Progression.

Cancers·2022
Same author

CD4<sup>+</sup> T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion.

The Prostate·2020
See all related articles

Related Experiment Video

Updated: May 13, 2025

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
09:20

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

3.5K

Interleukin-33 and Obesity-Related Inflammation and Cancer.

Cameron Kowitt1,2, Qiuyang Zhang1,3,4,5

  • 1Department of Structural & Cellular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Encyclopedia
|April 16, 2025
PubMed
Summary

Interleukin-33 (IL-33) is a cytokine implicated in obesity-related inflammation and cancer. Its dual role in promoting or inhibiting tumors highlights its complex involvement in these conditions.

Keywords:
IL-33ST2cancerimmune responseinflammationobesity

More Related Videos

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
10:30

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

8.7K
Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

36.0K

Related Experiment Videos

Last Updated: May 13, 2025

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
09:20

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

3.5K
Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
10:30

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

8.7K
Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

36.0K

Area of Science:

  • Immunology
  • Oncology
  • Metabolic Diseases

Background:

  • Interleukin-33 (IL-33) is an IL-1 family cytokine central to type 2 immunity and inflammatory responses.
  • IL-33 signaling is triggered by tissue damage, impacting immune cell function.
  • Chronic inflammation characterizes obesity, a risk factor for various cancers.

Purpose of the Study:

  • To review the multifaceted roles of IL-33 in obesity-associated inflammation.
  • To explore the connection between IL-33, obesity, and cancer development.
  • To elucidate the dual protumorigenic and antitumorigenic effects of IL-33.

Main Methods:

  • Literature review of studies on IL-33, obesity, inflammation, and cancer.
  • Analysis of IL-33 expression and function in adipose tissue.
  • Examination of IL-33's context-dependent effects on tumor biology.

Main Results:

  • IL-33 and its receptor are expressed in adipose tissue, suggesting a role in obesity.
  • IL-33's function in obesity-related inflammation is complex and not fully understood.
  • IL-33 can act as either a tumor promoter or suppressor depending on the cellular and inflammatory context.

Conclusions:

  • IL-33 is a key player in the inflammatory milieu of obesity.
  • The precise impact of IL-33 on obesity-associated cancers requires further investigation.
  • Understanding IL-33's dual role is critical for therapeutic strategies targeting obesity and cancer.