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Missing Teeth as an Early Predictive "Sign" for Atherosclerosis: A Retrospective Study
Junaid Ahmed1, Thilak Nithin2, Nanditha Sujir2
1Department of Oral Medicine and Radiology Manipal College of Dental Sciences Mangalore Manipal Academy of Higher Education Karnataka, India, 575001.
ARYA Atherosclerosis
|April 16, 2025
Summary
Tooth loss is linked to calcifications in the internal carotid artery (ICA). More missing teeth increase the likelihood of detecting ICA calcifications, suggesting a connection between periodontal health and systemic vascular disease.
Area of Science:
- Oral Health and Systemic Disease
- Vascular Biology
- Periodontology
Background:
- Periodontal pathogens and inflammation may contribute to systemic conditions like atherosclerosis.
- This study explores the link between internal carotid artery (ICA) calcifications and dental health.
Purpose of the Study:
- To investigate the correlation between incidental internal carotid artery (ICA) calcifications and tooth loss.
- To assess the relationship between ICA calcifications and periodontal status.
Main Methods:
- Retrospective analysis of 110 cone-beam computed tomography (CBCT) scans.
- Evaluation of CBCT scans for missing teeth and ICA calcifications.
- Analysis of patient demographics and number of missing teeth in relation to calcifications.
Main Results:
- 17% of CBCT scans showed ICA calcifications.
- Patients with ICA calcifications had a statistically significant higher number of missing teeth (P=0.01).
- Apical lesions were also significantly more prevalent in the group with ICA calcifications (P=0.011).
Conclusions:
- Increased tooth loss is associated with a higher prevalence of ICA calcifications.
- This finding suggests a potential link between oral health and carotid artery calcification.
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