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Sesquiterpene lactones from Carpesium abrotanoides L. fruits: characterization and bioactivity profiling
Peng-Bo Tang1, Xin-Yu Zhang1, Chao Zhang1
1School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, P. R. China.
Abstract:
Carpesium abrotanoides L. fruit serves as a key anthelmintic remedy in herbal medicine of China. As a continuation of previous research, two undescribed sesquiterpene lactones, carpeabrolactones A and B (1 and 2), and four known sesquiterpenoids (3-6) were obtained from the dichloromethane extract of fruits. The structures were established through sufficient spectral data examination and ECD calculation. Compound 3 displayed moderate anti-influenza A (H3N2) activity (IC50 = 37.04 μM). In addition, acetylcholinesterase (AchE) inhibitory effects of the isolates were also evaluated in vitro, but none of these presented obvious anti-AchE activities.
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